US 12,187,663 B2
Thyromimetics with a biphenylmethane scaffold and their use
Guido Puricelli, Milan (IT); Simona Rapposelli, Lucca (IT); Grazia Chiellini, Rosignano Solvay (IT); Amedeo Columbano, Selargius (IT); Andrea Perra, Quartu Sant'Elena (IT); Massimiliano Runfola, Fordongianus (IT); and Sheraz Gul, Hamburg (DE)
Assigned to INTERNATIONAL SOCIETY FOR DRUG DEVELOPMENT S.R.L., Milan (IT)
Appl. No. 17/611,188
Filed by INTERNATIONAL SOCIETY FOR DRUG DEVELOPMENT S.R.L., Milan (IT)
PCT Filed Mar. 10, 2020, PCT No. PCT/EP2020/056388
§ 371(c)(1), (2) Date Nov. 15, 2021,
PCT Pub. No. WO2020/229014, PCT Pub. Date Nov. 19, 2020.
Claims priority of application No. 102019000006923 (IT), filed on May 16, 2019.
Prior Publication US 2022/0227698 A1, Jul. 21, 2022
Int. Cl. C07C 233/11 (2006.01); A61P 1/16 (2006.01); C07D 209/08 (2006.01); C07D 215/28 (2006.01)
CPC C07C 233/11 (2013.01) [A61P 1/16 (2018.01); C07D 209/08 (2013.01); C07D 215/28 (2013.01)] 16 Claims
 
1. A compound of Formula (I) or a salt thereof:

OG Complex Work Unit Chemistry
Wherein
R1 is H, (C1-C3)alkyl or CF3;
R2 is H, (C1-C3)alkyl or CF3;
A is CH2COOH, XCH2COOCH2CH3, XCH2COOH, XCH2CH2NH2, where X is nitrogen or oxygen atom;
Ar is an aromatic fragment selected from the group consisting of

OG Complex Work Unit Chemistry
where
R3 is H, —CH3, —CH2CH3 or CH3CO—,
R4 is H or —CH3,
R5 is H or —CH3, and
R6 is H or —CH3.