US 12,186,751 B2
Devices and systems incorporating acoustic ordering and methods of use thereof
Alireza Salmanzadeh, Pleasanton, CA (US); and Rajiv Bharadwaj, Pleasanton, CA (US)
Assigned to 10x Genomics, Inc., Pleasanton, CA (US)
Filed by 10X Genomics, Inc., Pleasanton, CA (US)
Filed on Jun. 29, 2020, as Appl. No. 16/915,240.
Claims priority of provisional application 62/868,566, filed on Jun. 28, 2019.
Prior Publication US 2020/0406261 A1, Dec. 31, 2020
Int. Cl. B01L 3/00 (2006.01)
CPC B01L 3/502761 (2013.01) [B01L 2200/027 (2013.01); B01L 2200/0652 (2013.01); B01L 2400/0496 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A device for ordering particles in a liquid, comprising:
a) a first channel having a first inlet and a first outlet; and
b) a first source of acoustic energy operatively coupled to the first channel to produce an acoustic wave having a first plurality of evenly spaced nodes disposed longitudinally in the first channel to generate evenly spaced first particles in a first liquid in the first channel in the direction of flow;
c) a first pump configured to transport the first particles in the first channel;
d) a second channel having a second inlet and a second outlet, wherein the second channel has an intersection with the first channel between the first inlet and the first outlet;
e) a second source of acoustic energy operatively coupled to the second channel to produce an acoustic wave having a second plurality of evenly spaced nodes disposed longitudinally in the second channel to generate evenly spaced second particles in a second liquid in the second channel in the direction of flow;
f) a second pump configured to transport the second particles in the second channel; and
g) a third channel, wherein the third channel has an intersection with the first channel between (i) the intersection of the second channel and (ii) the first channel outlet.