	US 12,186,713 B2
	Non-woven fiber membranes
William Cataldo, Bradford, MA (US); Inga Elkina, Wilmington, MA (US); Kamran Beyzavi, Livingston (GB); Thomas Fitzgerald, Killarney (IE); Dennis Aquino, Chelmsford, MA (US); Daniel Callahan, Acton, MA (US); Michael Mansfield, Bedford, MA (US); Mikhail Kozlov, Lexington, MA (US); Gabriel Tkacik, Bedford, MA (US); Murugan Rajendiran, Carrigtwohill (IE); and Ramesh Babu Padamati, Dublin (IE)
Assigned to Merck Millipore Ltd., Carrigtwohill (IE); and The Provost Fellows Foundation Scholars and the Other Members of Board of the College of the Holy Cross, Dublin (IE)
Appl. No. 16/631,572
Filed by MERCK MILLIPORE LTD., Carrigtwohill (IE); and THE PROVOST FELLOWS FOUNDATION SCHOLARS AND THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN, Dublin (IE)
PCT Filed Jul. 20, 2018, PCT No. PCT/IB2018/000918 § 371(c)(1), (2) Date Jan. 16, 2020, PCT Pub. No. WO2019/016605, PCT Pub. Date Jan. 24, 2019.
Claims priority of provisional application 62/535,586, filed on Jul. 21, 2017.
Prior Publication US 2020/0173076 A1, Jun. 4, 2020
Int. Cl. B01D 71/40 (2006.01); B01D 39/16 (2006.01); B01D 69/10 (2006.01); D01D 5/00 (2006.01); D04H 1/728 (2012.01); G01N 33/543 (2006.01)

CPC B01D 71/4011 (2022.08) [B01D 69/107 (2022.08); D01D 5/003 (2013.01); D04H 1/728 (2013.01); G01N 33/54388 (2021.08); B01D 39/1623 (2013.01); B01D 2239/025 (2013.01); B01D 2239/0631 (2013.01); B01D 2239/1233 (2013.01); B01D 2323/39 (2013.01)]

23 Claims

1. A non-woven fiber membrane comprising nanofibers comprising a polymer blend of polymethylmethacrylate (PMMA) and poly(vinylidene difluoride) (PVDF), having an average fiber diameter from 200 nm to 1000 nm, wherein the membrane has a mean flow pore diameter of greater than about 1 micron to about 5 microns and a porosity of at least 80% and wherein said membrane is located in an assay developing region within a lateral flow diagnostic device.