US 12,186,577 B2
Methods and systems for efficient coupling of light from outside tissue to small volumes inside tissue
Hooman Mohseni, Wilmette, IL (US)
Assigned to Northwestern University, Evanston, IL (US)
Appl. No. 17/274,500
Filed by Northwestern University, Evanston, IL (US)
PCT Filed Sep. 9, 2019, PCT No. PCT/US2019/050150
§ 371(c)(1), (2) Date Mar. 9, 2021,
PCT Pub. No. WO2020/055718, PCT Pub. Date Mar. 19, 2020.
Claims priority of provisional application 62/730,099, filed on Sep. 12, 2018.
Prior Publication US 2022/0047886 A1, Feb. 17, 2022
Int. Cl. A61N 5/06 (2006.01)
CPC A61N 5/0613 (2013.01) [A61N 2005/0626 (2013.01); A61N 2005/063 (2013.01); A61N 2005/0658 (2013.01); A61N 2005/0665 (2013.01)] 13 Claims
OG exemplary drawing
 
1. A system to couple light to tissue, the system comprising:
a first light source configured to emit first light of a first wavelength λ1;
a second light source configured to emit second light of a second wavelength λ2;
a splitter/mixer configured to receive the first light and the second light and to pass the received first light and second light to a circulator; and
a retro-modulator configured to receive the first light and the second light, wherein the retro-modulator is configured to:
modulate the first light of the first wavelength λ1 based at least in part on an intensity of the second light of the second wavelength λ2; and
reflect the modulated first light to generate a guide-star within the tissue.