US 12,186,564 B2
Methods and apparatuses for treating stroke using low-frequency stimulation
Karunesh Ganguly, San Francisco, CA (US); Preeya Khanna, San Francisco, CA (US); and Kyungsoo Kim, Oakland, CA (US)
Assigned to The Regents of the University of California, Oakland, CA (US); and U.S. Government as represented by the Department of Veterans Affairs, Washington, DC (US)
Appl. No. 18/264,926
Filed by The Regents of the University of California, Oakland, CA (US); and U.S. Government as represented by the Department of Veterans Affairs, Washington, DC (US)
PCT Filed Feb. 9, 2022, PCT No. PCT/US2022/015876
§ 371(c)(1), (2) Date Aug. 9, 2023,
PCT Pub. No. WO2022/173871, PCT Pub. Date Aug. 18, 2022.
Claims priority of provisional application 63/147,745, filed on Feb. 9, 2021.
Prior Publication US 2024/0033516 A1, Feb. 1, 2024
Int. Cl. A61N 1/36 (2006.01)
CPC A61N 1/36103 (2013.01) [A61N 1/36139 (2013.01); A61N 1/36171 (2013.01); A61N 1/36178 (2013.01)] 33 Claims
OG exemplary drawing
 
1. A method of treating a patient, the method comprising:
detecting a directed movement or an intended directed movement from the patient; and
applying a charge-balanced, low-frequency alternating current stimulation (ACS) to a region of the patient's brain immediately before and/or during the directed movement, wherein the charge-balanced, low-frequency ACS has a depolarizing phase with a frequency of 15 Hz or less and a hyperpolarizing phase with a frequency greater than 15 Hz, wherein applying the charge-balanced, low-frequency ACS to the region of the patient's brain comprises applying the charge-balanced, low-frequency ACS to a region of the patient's brain that is adjacent to a lesion of the patient's brain;
wherein the ACS field strength is greater than 1.5 V/m.