US 12,186,529 B2
Drug delivery device
David Staub, Courtelevant (FR); Thierry Martin, Mont de Vougney (FR); Nicolas Bailo, Nidau (CH); and Denis Tilloy, Sonceboz (CH)
Assigned to SOCIETE INDUSTRIELLE DE SONCEBOZ SA, Sonceboz (CH)
Filed by SOCIETE INDUSTRIELLE DE SONCEBOZ SA, Sonceboz (CH)
Filed on Jan. 21, 2022, as Appl. No. 17/581,315.
Application 17/581,315 is a division of application No. 16/482,213, granted, now 11,413,392, previously published as PCT/EP2018/052179, filed on Jan. 29, 2018.
Claims priority of application No. 17153997 (EP), filed on Jan. 31, 2017.
Prior Publication US 2022/0143311 A1, May 12, 2022
Int. Cl. A61M 5/142 (2006.01); A61M 5/14 (2006.01); A61M 5/145 (2006.01); A61M 5/158 (2006.01); A61M 5/168 (2006.01); F04B 7/04 (2006.01)
CPC A61M 5/14248 (2013.01) [A61M 5/1409 (2013.01); A61M 5/14216 (2013.01); A61M 5/1454 (2013.01); A61M 5/16809 (2013.01); A61M 5/16827 (2013.01); A61M 2005/14252 (2013.01); A61M 2005/14506 (2013.01); A61M 2005/14533 (2013.01); A61M 2005/1585 (2013.01); A61M 2005/1588 (2013.01); F04B 7/045 (2013.01)] 11 Claims
OG exemplary drawing
 
1. A pump system for a drug delivery device, the pump system comprising a pump drive and a pump having a pump housing comprising an inlet port and an outlet port and forming a pump chamber containing a pump piston and a valve piston, wherein the pump comprises a valve channel configured to selectively connect and disconnect at least one of the inlet and outlet ports of the pump housing to the pump chamber as a function of a position of the valve piston, wherein the pump piston and the valve piston are linearly slidable along a common axis within the pump chamber, wherein the valve piston and the pump piston are independently actuated, wherein the valve piston comprises an over-molded part comprising a valve channel portion configured to engage an inner surface of the pump housing so as to form the valve channel with said inner surface, and wherein the over-molded part is configured to selectively seal the inlet and outlet ports from the pump chamber.
 
8. A drug reconstitution device including a pump system, the pump system comprising a pump drive and a pump having a pump housing comprising an inlet port and an outlet port and forming a pump chamber containing a pump piston and a valve piston, wherein the pump comprises a valve channel configured to selectively connect and disconnect at least one of the inlet and outlet ports of the pump housing to the pump chamber as a function of a position of the valve piston, wherein the pump piston and the valve piston are linearly slidable along a common axis within the pump chamber, and wherein the valve piston and the pump piston are independently actuated, wherein the pump housing comprises an additional port, said additional port and the inlet port corresponding to first and second drug reconstitution ports, wherein the drug reconstitution device is configured for coupling a first constituent container containing a first constituent and a second constituent container containing a second constituent, wherein the outlet port of the pump housing is configured to deliver a reconstituted drug comprising the first and second constituents, the drug reconstitution device further comprising a docking interface comprising a first and a second container docking interface configured to interconnect the first and second constituent containers respectively with the first and second drug reconstitution ports of the pump housing in a fluidic manner.
 
9. A method for reconstituting a drug using a pump system comprising a pump drive and a pump having a pump housing, the pump housing comprising a first drug reconstitution port, a second drug reconstitution port and an outlet port, the pump housing forming a pump chamber containing a pump piston and a valve piston, wherein the pump comprises a valve channel configured to selectively connect and disconnect at least one of the first and second drug reconstitution ports to the pump chamber as a function of a position of the valve piston and wherein the valve piston and the pump piston are independently actuated, the method comprising the following steps:
i) setting the valve piston in a first axial position in which the first and second drug reconstitution ports of the pump housing are in fluid communication;
ii) urging a first constituent contained in a first container through the valve channel into a second container containing a second constituent in order to reconstitute the drug inside the second container during a drug reconstitution phase;
iii) driving the pump piston away from the valve piston along a pump axis to draw the reconstituted drug from the second container into the pump chamber during a chamber filing phase;
iv) driving the valve piston in a second axial position, upon completion of the chamber filling phase, in which the valve channel is aligned with the outlet port while the first and second drug reconstitution ports are closed by the valve piston; and
v) driving the pump piston towards the valve piston along the pump axis to expel the reconstituted drug from the pump chamber, through the valve channel and the outlet port during a drug administration phase.