	US 12,186,455 B2
	Compositions and methods for promoting patency of vascular grafts
Christopher Breuer, New Haven, CT (US); Themis Kyriakides, New Haven, CT (US); and Jason Roh, New Haven, CT (US)
Assigned to YALE UNIVERSITY, New Haven, CT (US)
Filed by Yale University, New Haven, CT (US)
Filed on Apr. 5, 2022, as Appl. No. 17/713,766.
Application 15/850,364 is a division of application No. 12/811,676, granted, now 9,855,370, issued on Jan. 2, 2018, previously published as PCT/US2009/030407, filed on Jan. 8, 2009.
Application 17/713,766 is a continuation of application No. 15/850,364, filed on Dec. 21, 2017, abandoned.
Claims priority of provisional application 61/010,406, filed on Jan. 8, 2008.
Prior Publication US 2022/0226542 A1, Jul. 21, 2022
Int. Cl. A61L 27/50 (2006.01); A61K 38/19 (2006.01); A61L 27/18 (2006.01); A61L 27/54 (2006.01); A61F 2/06 (2013.01)

CPC A61L 27/507 (2013.01) [A61L 27/18 (2013.01); A61L 27/54 (2013.01); A61F 2/06 (2013.01); A61K 38/195 (2013.01); A61L 2300/426 (2013.01); A61L 2300/604 (2013.01)]

24 Claims

1. A biodegradable polymeric vascular graft comprising monocyte chemoattractant protein 1 (MCP-1) which is released in an amount between greater than zero and 200 ng per day from the time of implantation and over a period of one week or less effective to recruit an effective amount of host monocytes to the graft to promote neotissue formation at the site of implantation with reduced stenosis and increased patency of the graft in the host over time relative to the patency of the graft in the absence of the MCP-1.