	US 12,186,453 B2
	Materials with improved biocompatibility
Arturo J. Vegas, Belmont, MA (US); Joshua C. Doloff, Quincy, MA (US); Omid Veiseh, Cambridge, MA (US); Robert S. Langer, Newton, MA (US); and Daniel G. Anderson, Framingham, MA (US)
Assigned to MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Cambridge, MA (US); and THE CHILDREN'S MEDICAL CENTER CORPORATION, Boston, MA (US)
Filed by Massachusetts Institute of Technology, Cambridge, MA (US); and The Children's Medical Center Corporation, Boston, MA (US)
Filed on Nov. 2, 2016, as Appl. No. 15/341,118.
Application 15/341,118 is a continuation of application No. PCT/US2016/059966, filed on Nov. 1, 2016.
Claims priority of provisional application 62/249,323, filed on Nov. 1, 2015.
Prior Publication US 2018/0117216 A1, May 3, 2018 Prior Publication US 2019/0046690 A9, Feb. 14, 2019
Int. Cl. A61L 27/38 (2006.01); A61K 9/00 (2006.01); A61K 35/36 (2015.01); A61K 38/02 (2006.01); A61L 27/04 (2006.01); A61L 27/10 (2006.01); A61L 27/16 (2006.01); A61L 27/18 (2006.01); A61L 27/20 (2006.01); A61L 27/34 (2006.01); A61L 27/54 (2006.01); A61L 27/56 (2006.01); A61L 29/14 (2006.01); C08J 7/12 (2006.01); A61K 35/12 (2015.01); A61K 35/39 (2015.01)

CPC A61L 27/3804 (2013.01) [A61K 9/0051 (2013.01); A61K 35/36 (2013.01); A61K 38/02 (2013.01); A61L 27/04 (2013.01); A61L 27/10 (2013.01); A61L 27/16 (2013.01); A61L 27/18 (2013.01); A61L 27/20 (2013.01); A61L 27/34 (2013.01); A61L 27/3813 (2013.01); A61L 27/3839 (2013.01); A61L 27/54 (2013.01); A61L 27/56 (2013.01); A61L 29/14 (2013.01); C08J 7/12 (2013.01); A61K 35/12 (2013.01); A61K 2035/128 (2013.01); A61K 35/39 (2013.01); A61L 2300/252 (2013.01); A61L 2300/254 (2013.01); A61L 2400/18 (2013.01)]

22 Claims

1. A macroscopic implant comprising a chemical moiety covalently bound to a polymer selected from polytetrafluoroethylene, polyurethane, polydimethylsiloxane, and poly(vinyl) chloride, wherein the polymer is present on a surface of the macroscopic implant, and wherein the chemical moiety is selected from the group consisting of: