	US 12,186,447 B2
	Pectin-carboxymethylcellulose mesothelial sealants and protectants
Steven James Mentzer, Boston, MA (US); Cristian David Valenzuela, Boston, MA (US); Alexandra Brooke Ysasi, Providence, RI (US); and Andrew Barrett Servais, Boston, MA (US)
Assigned to The Brigham and Women's Hospital, Inc., Boston, MA (US)
Filed by The Brigham and Women's Hospital, Inc., Boston, MA (US)
Filed on Dec. 23, 2022, as Appl. No. 18/146,081.
Application 18/146,081 is a continuation of application No. 17/164,270, filed on Feb. 1, 2021, granted, now 11,534,524.
Application 17/164,270 is a continuation of application No. 15/967,071, filed on Apr. 30, 2018, granted, now 10,912,858, issued on Feb. 9, 2021.
Claims priority of provisional application 62/492,363, filed on May 1, 2017.
Prior Publication US 2023/0211042 A1, Jul. 6, 2023
Int. Cl. A61L 24/04 (2006.01); A61L 24/00 (2006.01)

CPC A61L 24/043 (2013.01) [A61L 24/001 (2013.01); A61L 24/0015 (2013.01); A61L 24/0042 (2013.01); A61L 2300/414 (2013.01)]

20 Claims

1. A pectin-based polymer film composition comprising:

two or more layers,

wherein a first layer of the two or more layers is a first bioadhesive polymer film comprising: i) a pectin selected from 100 weight percentage (wt %) high methoxyl pectin (HMP), and ii) water,

wherein a second layer of the two or more layers is a second polymer film comprising less than 15 wt % pectin,

wherein the second polymer film is non-bioadhesive or has reduced bio-adhesiveness as compared to the first bioadhesive polymer film, and

wherein the first bioadhesive polymer film and the second polymer film each have a thickness selected from about 40 microns to about 900 microns.