US 12,186,431 B2
Pharmaceutical dosage form for application to mucous membranes
Malte Bogdahn, Greifswald (DE); Kirsten Kirsch, Greifswald (DE); Michael Grimm, Greifswald (DE); Mirko Koziolek, Greifswald (DE); and Werner Weitschies, Greifswald (DE)
Assigned to EsoCap AG, Basil (CH)
Filed by EsoCap AG, Basel (CH)
Filed on Jul. 2, 2020, as Appl. No. 16/920,341.
Application 16/920,341 is a division of application No. 15/539,596, granted, now 10,744,095, previously published as PCT/EP2015/002601, filed on Dec. 22, 2015.
Claims priority of application No. 102014119576 (DE), filed on Dec. 23, 2014.
Prior Publication US 2020/0397708 A1, Dec. 24, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/48 (2006.01); A61J 7/00 (2006.01); A61K 9/00 (2006.01); A61K 9/70 (2006.01); A61K 31/196 (2006.01); A61K 31/56 (2006.01); A61K 31/58 (2006.01); A61K 45/06 (2006.01); A61M 31/00 (2006.01); A61K 47/32 (2006.01)
CPC A61K 9/4808 (2013.01) [A61J 7/0092 (2013.01); A61K 9/0031 (2013.01); A61K 9/0034 (2013.01); A61K 9/006 (2013.01); A61K 9/7007 (2013.01); A61K 9/7069 (2013.01); A61K 9/7084 (2013.01); A61K 31/196 (2013.01); A61K 31/56 (2013.01); A61K 31/58 (2013.01); A61K 45/06 (2013.01); A61M 31/00 (2013.01); A61M 31/002 (2013.01); A61K 9/0036 (2013.01); A61K 9/703 (2013.01); A61K 47/32 (2013.01)] 18 Claims
 
1. A pharmaceutical dosage form (1) for the application to a gastrointestinal mucous membrane, comprising at least
a film shaped, foil shaped or wafer shaped, preparation (3) comprising the active pharmaceutical ingredient,
a release mechanism (4) and
a trigger mechanism (5), wherein
the trigger mechanism (5) is adapted to trigger, at a predetermined site of action of the gastrointestinal tract, the release of the film shaped, foil shaped or wafer shaped preparation (3) by the release mechanism (4);
further comprising a shell (2), wherein the shell (2) contains the film shaped, foil shaped or wafer shaped preparation (3) comprising the active pharmaceutical ingredient, and wherein the shell (2) comprises at least one aperture (6), wherein the trigger mechanism is a holding device which is exposed to the outside of the shell, wherein the holding device is a broadened part of the preparation (3) or is attached to the preparation, and wherein the release mechanism comprises a string member, wherein the preparation (3) is mucoadhesive and is adapted to at least partially form the string member, and wherein the string member is mucoadhesive.