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1. A method of improving a cosmetic condition or aesthetic appearance of skin on a subject, the method comprising: topically administering to the skin of the subject in need thereof, a formulation comprising a peptide comprising an amino acid sequence of QHREDGS (SEQ ID NO: 1), in an amount effective to improve the cosmetic condition or aesthetic appearance of the skin, wherein the improvement of the cosmetic condition or aesthetic appearance of the skin is at least one of: reducing dermatological signs of chronological aging, photo-aging, hormonal aging, or actinic aging; reducing the appearance of lines or wrinkles; reducing noticeability of facial lines and wrinkles, facial wrinkles on cheeks, forehead, perpendicular wrinkles between eyes, horizontal wrinkles above eyes, and around mouth, marionette lines; reducing, or diminishing the appearance or depth of lines or wrinkles; improving the appearance of suborbital lines or periorbital lines; reducing the appearance of crow's feet; rejuvenating or revitalizing skin; reducing skin fragility; reversing of loss of glycosaminoglycans or collagen; ameliorating effects of estrogen imbalance; skin atrophy; reducing, or treating hyperpigmentation; minimizing skin discoloration; improving skin tone, radiance, clarity or tautness; reducing, or ameliorating skin sagging; improving skin firmness, plumpness, suppleness or softness; improving procollagen or collagen production; improving skin texture or promoting retexturization; improving skin barrier repair or function; improving the appearance of skin contours; restoring skin luster and/or brightness; minimizing dermatological sings of fatigue or stress; resisting environmental stress; replenishing ingredients in the skin decreased by aging or menopause; improving communication among skin cells; increasing cell proliferation or multiplication; increasing skin cell metabolism decreased by aging or menopause; retarding cellular aging, improving skin moisturization; enhancing skin thickness; increasing skin elasticity or resiliency; enhancing exfoliation; improving microcirculation; or decreasing cellulite formation.
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