US 12,186,413 B2
Non-cellular root canal filler and non-cellular dental tissue regeneration promotion kit
Misako Nakashima, Aichi (JP); and Koichiro Iohara, Aichi (JP)
Assigned to KOWA COMPANY, LTD., Aichi (JP)
Appl. No. 17/441,611
Filed by KOWA COMPANY, LTD., Aichi (JP)
PCT Filed Mar. 27, 2020, PCT No. PCT/JP2020/014166
§ 371(c)(1), (2) Date Sep. 21, 2021,
PCT Pub. No. WO2020/196867, PCT Pub. Date Oct. 1, 2020.
Claims priority of application No. 2019-062054 (JP), filed on Mar. 28, 2019.
Prior Publication US 2022/0362109 A1, Nov. 17, 2022
Int. Cl. A61K 6/54 (2020.01); A61K 6/69 (2020.01); A61K 6/80 (2020.01); A61K 31/4375 (2006.01); A61K 31/4439 (2006.01); A61K 31/451 (2006.01); A61K 31/4725 (2006.01); A61K 38/18 (2006.01); A61K 38/19 (2006.01); A61K 38/48 (2006.01); A61K 45/06 (2006.01); A61L 27/22 (2006.01); A61L 27/36 (2006.01); A61L 27/54 (2006.01); A61P 1/02 (2006.01)
CPC A61K 6/54 (2020.01) [A61K 6/69 (2020.01); A61K 6/80 (2020.01); A61K 31/4375 (2013.01); A61K 31/4439 (2013.01); A61K 31/451 (2013.01); A61K 31/4725 (2013.01); A61K 38/1825 (2013.01); A61K 38/193 (2013.01); A61K 38/195 (2013.01); A61K 38/4826 (2013.01); A61K 45/06 (2013.01); A61L 27/22 (2013.01); A61L 27/3633 (2013.01); A61L 27/54 (2013.01); A61P 1/02 (2018.01); C12Y 304/21004 (2013.01); A61L 2300/412 (2013.01); A61L 2300/414 (2013.01); A61L 2300/434 (2013.01); A61L 2300/436 (2013.01); A61L 2430/12 (2013.01)] 12 Claims
 
1. A non-cellular root canal filler comprising a tetrahydroisoquinoline compound, wherein the tetrahydroisoquinoline compound is selected from the group consisting of:
(+)-4-[[2-[6-fluoro-3-(4-fluorobenzyl)-3,4-dihydroisoquinolin-2 (1H-yl]ethylamino]methyl]-N-isopropylaniline monofumarate; and
(+)-N-[3-(methanesulfonylamino)benzyl]-2-[6-fluoro-3-(4-fluorobenzyl)-3,4-dihydroisoquinolin-2 (1H)-yl]ethanamine monocitrate.