	US 12,186,408 B2
	Fusion polypeptides for inhibiting angiogenesis, fusion protein nanocages having multivalent peptides for inhibiting angiogenesis, and theranostic use thereof
Dong Woo Lim, Seoul (KR); and Min Jung Kang, Gyeonggi-do (KR)
Assigned to Industry-University Cooperation Foundation Hanyang University Erica Campus, Gyeonggi-Do (KR)
Appl. No. 17/604,414
Filed by INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY ERICA CAMPUS, Gyeonggi-do (KR)
PCT Filed Apr. 17, 2020, PCT No. PCT/KR2020/005176 § 371(c)(1), (2) Date Oct. 16, 2021, PCT Pub. No. WO2020/213993, PCT Pub. Date Oct. 22, 2020.
Claims priority of application No. 10-2019-0045484 (KR), filed on Apr. 18, 2019; and application No. 10-2020-0046920 (KR), filed on Apr. 17, 2020.
Prior Publication US 2022/0331453 A1, Oct. 20, 2022
Int. Cl. A61K 49/00 (2006.01); A61K 38/00 (2006.01); A61P 9/00 (2006.01); C07K 14/435 (2006.01)

CPC A61K 49/0054 (2013.01) [A61P 9/00 (2018.01); C07K 14/435 (2013.01); A61K 38/00 (2013.01); A61K 49/0056 (2013.01); C07K 2319/00 (2013.01)]

15 Claims

1. A fusion polypeptide for inhibiting angiogenesis,

i) consisting of an anti-angiogenic peptide; a helix-based polypeptide represented by SEQ ID NO 1, which is linked to the peptide; a hydrophilic elastin-based polypeptide (hydrophilic EBP) linked to the helix-based peptide; and a helix-based polypeptide represented by SEQ ID NO 2, which is linked to the hydrophilic EBP,

ii) consisting of a helix-based polypeptide represented by SEQ ID NO 1; a first hydrophilic EBP linked to the peptide; an anti-angiogenic peptide linked to the first hydrophilic EBP; a second hydrophilic EBP linked to the anti-angiogenic peptide; and a helix-based polypeptide represented by SEQ ID NO 2, which is linked to the second hydrophilic EBP, or

iii) consisting of an anti-angiogenic peptide; a helix-based polypeptide represented by SEQ ID NO 1, which is linked to the peptide; a hydrophilic EBP linked to the helix-based polypeptide; an anti-angiogenic peptide linked to the hydrophilic EBP; a hydrophilic EBP linked to the anti-angiogenic peptide; and a helix-based polypeptide represented by SEQ ID NO 2, which is linked to the hydrophilic EBP.