US 12,186,398 B2
Non-ionic PVP-PLA block copolymers and liquid pharmaceutical compositions derived therefrom
Damon Smith, Montreal (CA); Wilms Baille, Laval (CA); and Piotr Kujawa, Montreal (CA)
Assigned to Altus Formulation Inc., Mirabel (CA)
Filed by ALTUS FORMULATION INC., Mirabel (CA)
Filed on Feb. 2, 2022, as Appl. No. 17/591,241.
Application 17/591,241 is a continuation of application No. 16/497,925, granted, now 11,266,741, previously published as PCT/CA2018/050399, filed on Mar. 29, 2018.
Claims priority of provisional application 62/479,582, filed on Mar. 31, 2017.
Claims priority of application No. 1705287 (GB), filed on Mar. 31, 2017.
Prior Publication US 2022/0152208 A1, May 19, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 47/34 (2017.01); A61K 9/107 (2006.01); A61K 9/51 (2006.01); A61K 31/05 (2006.01); A61K 31/167 (2006.01); A61K 31/192 (2006.01); A61K 31/415 (2006.01)
CPC A61K 47/34 (2013.01) [A61K 9/1075 (2013.01); A61K 9/5192 (2013.01); A61K 31/05 (2013.01); A61K 31/167 (2013.01); A61K 31/192 (2013.01); A61K 31/415 (2013.01)] 20 Claims
OG exemplary drawing
 
1. PVP-PLA block copolymers as defined in Formula I:

OG Complex Work Unit Chemistry
wherein:
x is an initiator alcohol having a boiling point greater than 145° C.,
n is, on average, from 20 and 40, and
m is, on average, from 10 and 40,
wherein the block coplymers have a number average molecular weight (Mn) of at least 3000 Da,
wherein the initiator alcohol is selected from the group consisting of:
1-hexanol;
1-heptanol;
diethylene glycol mono ethyl ether;
diethylene glycol mono methyl ether;
triethylene glycol mono methyl ether;
tetraethylene glycol mono methyl ether;
oligo-ethylene glycol mono methyl ethers of formula II

OG Complex Work Unit Chemistry
wherein a≥5;
oligo-ethylene glycol mono ethyl ethers of formula III

OG Complex Work Unit Chemistry
wherein b≥1; and
mixtures thereof.