US 12,186,396 B2
Branched multi-functional macromonomers and related polymers and uses thereof
Jeremiah A. Johnson, Boston, MA (US); Nolan Gallagher, Cambridge, MA (US); Farrukh Vohidov, Cambridge, MA (US); Yivan Jiang, Revere, MA (US); and Hung Vanthanh Nguyen, Braintree, MA (US)
Assigned to Massachusetts Institute of Technology, Cambridge, MA (US)
Filed by Massachusetts Institute of Technology, Cambridge, MA (US)
Filed on May 23, 2022, as Appl. No. 17/751,540.
Application 16/898,331 is a division of application No. 16/024,662, filed on Jun. 29, 2018, granted, now 10,716,858.
Application 17/751,540 is a continuation of application No. 16/898,331, filed on Jun. 10, 2020, granted, now 11,338,038.
Claims priority of provisional application 62/528,010, filed on Jun. 30, 2017.
Prior Publication US 2023/0068959 A1, Mar. 2, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 47/18 (2017.01); A61K 47/34 (2017.01); A61K 47/59 (2017.01); A61P 35/00 (2006.01); B01J 31/22 (2006.01); C07D 403/14 (2006.01); C07D 405/14 (2006.01); C08G 61/08 (2006.01); C08G 69/48 (2006.01); C08G 83/00 (2006.01); C08L 71/02 (2006.01); G01N 33/574 (2006.01)
CPC A61K 47/18 (2013.01) [A61K 47/34 (2013.01); A61K 47/595 (2017.08); A61P 35/00 (2018.01); B01J 31/2278 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C08G 61/08 (2013.01); C08G 69/48 (2013.01); C08G 83/00 (2013.01); C08L 71/02 (2013.01); G01N 33/574 (2013.01); B01J 2523/821 (2013.01); C08G 2261/135 (2013.01); C08G 2261/136 (2013.01); C08G 2261/1414 (2013.01); C08G 2261/1424 (2013.01); C08G 2261/1426 (2013.01); C08G 2261/1432 (2013.01); C08G 2261/418 (2013.01); C08G 2261/76 (2013.01)] 24 Claims
 
1. A macromonomer of Formula (I):

OG Complex Work Unit Chemistry
or a salt thereof, wherein:
each instance of RA is independently hydrogen, halogen, or substituted or unsubstituted, C1-6 alkyl;
a is an integer from 1 to 20, inclusive;
each instance of M is independently hydrogen or an agent;
each instance of m is independently an integer from 1 to 10, inclusive;
each instance of L is independently substituted or unsubstituted, C1-200 alkylene, substituted or unsubstituted, C2-200 alkenylene, substituted or unsubstituted, C2-200 alkynylene, substituted or unsubstituted, C2-200 heteroalkylene, substituted or unsubstituted, C2-200 heteroalkenylene, or substituted or unsubstituted, C2-200 heteroalkynylene, wherein:
optionally one or more carbons in each instance of the substituted or unsubstituted, C1-200 alkylene, substituted or unsubstituted, C2-200 alkenylene, substituted or unsubstituted, C2-200 alkynylene, substituted or unsubstituted, C2-200 heteroalkylene, substituted or unsubstituted, C2-200 heteroalkenylene, and substituted or unsubstituted, C2-200 heteroalkynylene are independently replaced with substituted or unsubstituted carbocyclylene, substituted or unsubstituted heterocyclylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene;
optionally one or more heteroatoms in each instance of the substituted or unsubstituted, C2-200 heteroalkylene, substituted or unsubstituted, C2-200 heteroalkenylene, and substituted or unsubstituted, C2-200 heteroalkynylene are independently replaced with substituted or unsubstituted carbocyclylene, substituted or unsubstituted heterocyclylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene;
provided that when each instance of M is hydrogen, at least one instance of -L(M)m comprises a click-chemistry handle;
each instance of RB is independently hydrogen, halogen, or substituted or unsubstituted, C1-6 alkyl;
each instance of b is independently an integer from 1 to 20, inclusive;
e is an integer from 1 to 10, inclusive;
X is —ORC or —N(RD)2, wherein:
RC is hydrogen, substituted or unsubstituted, C1-1000 alkyl, substituted or unsubstituted, C2-1000 alkenyl, substituted or unsubstituted, C2-1000 alkynyl, substituted or unsubstituted, C1-1000 heteroalkyl, substituted or unsubstituted, C2-1000 heteroalkenyl, substituted or unsubstituted, C2-1000 heteroalkynyl, an oxygen protecting group, or a leaving group; and
each instance of RD is independently hydrogen, substituted or unsubstituted, C1-1000 alkyl, substituted or unsubstituted, C2-1000 alkenyl, substituted or unsubstituted, C2-1000 alkynyl, substituted or unsubstituted, C1-1000 heteroalkyl, substituted or unsubstituted, C2-1000 heteroalkenyl,-substituted or unsubstituted, C2-1000 heteroalkynyl, or a nitrogen protecting group, or two RD are taken together to form a substituted or unsubstituted heterocyclyl or substituted or unsubstituted heteroaryl moiety.