US 12,186,394 B2
Compositions and methods for treatment of pre-cancerous skin lesions
Lynn Cornelius, St. Louis, MO (US); Shadmehr Demehri, St. Louis, MO (US); and Raphael Kopan, St. Louis, MO (US)
Assigned to Washington University, St. Louis, MO (US)
Filed by Washington University, St. Louis, MO (US)
Filed on Sep. 16, 2022, as Appl. No. 17/946,905.
Application 17/946,905 is a continuation of application No. 17/140,782, filed on Jan. 4, 2021, granted, now 11,478,549.
Application 17/140,782 is a continuation of application No. 15/510,443, granted, now 10,905,763, issued on Feb. 2, 2021, previously published as PCT/US2015/049434, filed on Sep. 10, 2015.
Claims priority of provisional application 62/048,586, filed on Sep. 10, 2014.
Prior Publication US 2023/0026855 A1, Jan. 26, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 243/04 (2006.01); A61K 31/513 (2006.01); A61K 31/59 (2006.01); A61K 31/593 (2006.01); A61K 45/06 (2006.01)
CPC A61K 45/06 (2013.01) [A61K 31/513 (2013.01); A61K 31/59 (2013.01); A61K 31/593 (2013.01); C07D 243/04 (2013.01); A61K 2300/00 (2013.01)] 19 Claims
 
1. A topical composition comprising about 2% to about 5% (wt/wt) 5-fluorouracil (5-FU) and about 0.002% to about 0.005% (wt/wt) calcipotriol.