	US 12,186,385 B2
	Immune complex
Jeffrey V. Ravetch, New York, NY (US); Taia Wang, New York, NY (US); and Jad Mamaary, New York, NY (US)
Assigned to The Rockefeller University, New York, NY (US)
Filed by The Rockefeller University, New York, NY (US)
Filed on May 18, 2023, as Appl. No. 18/319,865.
Application 17/301,626 is a division of application No. 16/408,517, filed on May 10, 2019, granted, now 10,973,904, issued on Apr. 13, 2021.
Application 16/408,517 is a division of application No. 15/560,074, granted, now 10,300,127, issued on May 28, 2019, previously published as PCT/US2016/023426, filed on Mar. 21, 2016.
Application 18/319,865 is a continuation of application No. 17/301,626, filed on Apr. 9, 2021, granted, now 11,690,905.
Claims priority of provisional application 62/136,064, filed on Mar. 20, 2015.
Prior Publication US 2023/0338505 A1, Oct. 26, 2023
Int. Cl. A61K 39/00 (2006.01); A61K 39/12 (2006.01); A61K 39/145 (2006.01); A61K 39/42 (2006.01); A61K 45/06 (2006.01); A61P 31/16 (2006.01); A61P 35/00 (2006.01); C07K 14/005 (2006.01); C07K 14/47 (2006.01); C07K 16/00 (2006.01); C07K 16/08 (2006.01); C07K 16/10 (2006.01); C07K 16/12 (2006.01); C07K 16/30 (2006.01)

CPC A61K 39/145 (2013.01) [A61K 39/0011 (2013.01); A61K 39/12 (2013.01); A61K 39/42 (2013.01); A61K 45/06 (2013.01); A61P 31/16 (2018.01); A61P 35/00 (2018.01); C07K 14/005 (2013.01); C07K 14/4748 (2013.01); C07K 16/1018 (2013.01); A61K 2039/505 (2013.01); A61K 2039/5252 (2013.01); A61K 2039/55516 (2013.01); C07K 2317/21 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/41 (2013.01); C07K 2317/72 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C12N 2760/16134 (2013.01)]

16 Claims

1. A fusion protein comprising (i) an antigenic segment and (ii) an IgG Fc region capable of binding to a Type II Fc receptor, wherein the IgG Fc region comprises a F241A mutation at a position corresponding to F241 of SEQ ID NO:1.