US 12,186,317 B2
Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
Roberto Pellicciari, Perugia (IT); Paride Liscio, Perugia (IT); Nicola Giacche, Perugia (IT); and Francesca De Franco, Perugia (IT)
Assigned to TES PHARMA S.R.L., Perugia (IT)
Filed by TES Pharma S.r.l., Perugia (IT)
Filed on Aug. 9, 2023, as Appl. No. 18/447,130.
Application 18/447,130 is a continuation of application No. 17/325,068, filed on May 19, 2021.
Application 17/325,068 is a continuation of application No. PCT/EP2019/081799, filed on Nov. 19, 2019.
Claims priority of provisional application 62/769,959, filed on Nov. 20, 2018.
Prior Publication US 2023/0381177 A1, Nov. 30, 2023
Int. Cl. A61K 31/513 (2006.01); A61K 31/4418 (2006.01); A61K 31/4436 (2006.01); A61K 31/5377 (2006.01); A61P 1/16 (2006.01); C07D 213/70 (2006.01); C07D 239/56 (2006.01); C07D 409/04 (2006.01); C07D 409/12 (2006.01); C07D 409/14 (2006.01)
CPC A61K 31/513 (2013.01) [A61K 31/4418 (2013.01); A61K 31/4436 (2013.01); A61K 31/5377 (2013.01); A61P 1/16 (2018.01); C07D 213/70 (2013.01); C07D 239/56 (2013.01); C07D 409/04 (2013.01); C07D 409/12 (2013.01); C07D 409/14 (2013.01)] 12 Claims
 
1. A compound represented by Formula (II):

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt or tautomer thereof, wherein:
X is O or ORh;
W is N;
L is —SCH2—;
R1 is absent, C6-C10 arylene or heteroarylene, wherein the heteroarylene comprises one or two 5- to 7-membered rings and 1-4 heteroatoms selected from N, O, and S, and wherein the C6-C10 arylene and heteroarylene are unsubstituted or substituted with one to two Re;
each R6 is independently at each occurrence H or C1-C4 alkyl;
R7 is A;
A is —(C(R6)2)rtetrazole;
Rc is H, halogen, or —CN;
Rd is —CF3, —CRfF2, —(C(R6)2)t—C6-C10 aryl, —(C(R6)2)t-5- or 6-membered heteroaryl;
each Re is independently at each occurrence C1-C6 alkyl, halogen, C1-C6 haloalkyl, —NHRz, —OH, or —CN;
Rf is H;
Rh is H;
Rj is absent;
Rz is H, C1-C6 alkyl, or C1-C6 haloalkyl;
each r is independently 0, 1, or 2;
each t is independently 1 or 2; and
custom character represents a single bond or a double bond.