	US 12,186,314 B2
	Compositions and methods for treatment, amelioration, and prevention of anesthesia-induced hypothermia
Amol Patwardhan, Tucson, AZ (US); Frank Porreca, Tucson, AZ (US); and Andrej Romanovsky, Phoenix, AZ (US)
Assigned to ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA, Tucson, AZ (US); and DIGNITY HEALTH, San Francisco, CA (US)
Appl. No. 16/065,441
Filed by ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA, Tucson, AZ (US); and DIGNITY HEALTH, San Francisco, CA (US)
PCT Filed Dec. 20, 2016, PCT No. PCT/US2016/067825 § 371(c)(1), (2) Date Jun. 22, 2018, PCT Pub. No. WO2017/112693, PCT Pub. Date Jun. 29, 2017.
Claims priority of provisional application 62/271,048, filed on Dec. 22, 2015.
Prior Publication US 2019/0008865 A1, Jan. 10, 2019
Int. Cl. A61K 31/506 (2006.01); A61K 9/00 (2006.01); A61K 31/165 (2006.01); A61K 31/357 (2006.01); A61K 31/416 (2006.01); A61K 31/55 (2006.01); A61M 16/01 (2006.01); A61P 43/00 (2006.01)

CPC A61K 31/506 (2013.01) [A61K 9/0019 (2013.01); A61K 9/0053 (2013.01); A61K 31/165 (2013.01); A61K 31/357 (2013.01); A61K 31/416 (2013.01); A61K 31/55 (2013.01); A61P 43/00 (2018.01); A61M 16/01 (2013.01)]

5 Claims

1. A method of preventing anesthesia-induced hypothermia in a mammalian subject in need thereof, comprising administering to the subject an ion channel TRPV1 inhibitor before or during an induction phase of anesthesia, wherein anesthesia-induced hypothermia is caused by administration of general anesthesia selected from at least one of an inhalation anesthetic or an intravenous anesthetic and wherein the ion channel TRPV1 inhibitor is selected from the group consisting of capsazepine, SB-366791, and A-1165442.