US 12,186,312 B2
Sleep improving agent
Kazunori Goto, Sapporo (JP); Jun Nakahigashi, Sapporo (JP); Atsuya Sato, Sapporo (JP); Yosuke Hirayama, Sapporo (JP); Moeri Horikoshi, Sapporo (JP); Noriyuki Kouda, Osaka (JP); Syoichiro Inoue, Osaka (JP); Ikutaro Sato, Osaka (JP); and Manami Kato, Osaka (JP)
Assigned to AMINO UP CO., LTD., Sapporo (JP); and OTSUKA PHARMACEUTICAL CO., LTD., Tokyo (JP)
Filed by Amino Up Co., Ltd., Sapporo (JP); and OTSUKA PHARMACEUTICAL CO., LTD., Tokyo (JP)
Filed on Sep. 9, 2022, as Appl. No. 17/941,627.
Application 17/941,627 is a division of application No. 16/839,889, filed on Apr. 3, 2020, granted, now 11,478,473.
Application 16/839,889 is a division of application No. 16/303,960, abandoned, previously published as PCT/JP2017/019644, filed on May 26, 2017.
Claims priority of application No. 2016-105477 (JP), filed on May 26, 2016.
Prior Publication US 2023/0017155 A1, Jan. 19, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/4985 (2006.01); A61P 25/20 (2006.01); A61P 25/22 (2006.01)
CPC A61K 31/4985 (2013.01) [A61P 25/20 (2018.01); A61P 25/22 (2018.01)] 5 Claims
OG exemplary drawing
 
1. A method for improving sleep-awakening rhythm, which comprises administrating to a subject a compound selected from the group consisting of
(3S,8aS)-3-isobutylhexahydropyrrolo [1,2-a]pyrazine-1,4-dione (Cyclo (L-Leu-L-Pro))

OG Complex Work Unit Chemistry
(3S,8aS)-3-benzylhexahydropyrrolo [1,2-a]pyrazine-1,4-dione (Cyclo (L-Phe-L-Pro))

OG Complex Work Unit Chemistry
and
(3S,8aS)-3-(4-hydroxybenzyl) hexahydropyrrolo [1,2-a]pyrazine-1,4-dione (Cyclo (L-Tyr-L-Pro))

OG Complex Work Unit Chemistry
or a salt thereof,
wherein the subject is selected from the group consisting of subjects who want to improve the shift of sleep-awakening rhythm and subjects who want to adjust sleeping/waking up rhythm.