US 12,186,279 B2
Sustained release cowpea mosaic virus or virus-like particle therapeutic constructs for the treatment of cancer
Nicole F. Steinmetz, San Diego, CA (US); Frank Alexander Veliz, Cleveland, OH (US); and Brylee David B. Tiu, Cleveland, OH (US)
Assigned to CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH (US)
Filed by CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH (US)
Filed on Sep. 6, 2022, as Appl. No. 17/903,286.
Application 17/903,286 is a continuation of application No. 16/319,765, granted, now 11,433,123, previously published as PCT/US2017/043342, filed on Jul. 21, 2017.
Claims priority of provisional application 62/364,949, filed on Jul. 21, 2016.
Prior Publication US 2023/0076403 A1, Mar. 9, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 47/69 (2017.01); A61K 39/00 (2006.01); A61K 39/385 (2006.01); A61K 39/39 (2006.01); A61P 35/00 (2006.01); B82Y 5/00 (2011.01)
CPC A61K 47/6901 (2017.08) [A61K 39/0011 (2013.01); A61K 39/385 (2013.01); A61K 39/39 (2013.01); A61P 35/00 (2018.01); A61K 2039/5258 (2013.01); A61K 2039/585 (2013.01); A61K 2039/622 (2013.01); A61K 2039/645 (2013.01); B82Y 5/00 (2013.01)] 10 Claims
 
1. A nanoparticle construct for in situ delivery of plant virus or plant virus-like particles to a cell or tissue of interest of a subject, the nanoparticle construct comprising:
a plurality of plant virus or plant virus-like particles, wherein the plant virus or plant virus-like particle is a rod-shaped virus particle, a plant picornavirus, or a filamentous plant virus or plant virus-like particle; and
a plurality of dendrimers electrostatically coupled to the plant virus or plant virus-like particles, the nanoparticle construct upon in situ delivery to a subject providing a sustained release of the plant virus or plant virus-like particles and/or dendrimers to the cell or tissue.