US 12,186,272 B2
Oral drug delivery device
Liang Chang Dong, Shanghai (CN); Yang Lei, Shanghai (CN); Gang Wu, Shanghai (CN); Yan Jiao, Shanghai (CN); and Jingmin Shi, Shanghai (CN)
Assigned to SHANGHAI WD PHARMACEUTICAL CO., LTD, Shanghai (CN)
Appl. No. 17/420,618
Filed by SHANGHAI WD PHARMACEUTICAL CO., LTD, Shanghai (CN)
PCT Filed Jan. 22, 2020, PCT No. PCT/CN2020/073865
§ 371(c)(1), (2) Date Jul. 2, 2021,
PCT Pub. No. WO2020/143843, PCT Pub. Date Jul. 16, 2020.
Claims priority of application No. 201910012935.4 (CN), filed on Jan. 7, 2019.
Prior Publication US 2022/0110832 A1, Apr. 14, 2022
Int. Cl. A61J 7/00 (2006.01); A61K 31/137 (2006.01); A61K 31/138 (2006.01); A61K 31/167 (2006.01); A61K 31/197 (2006.01); A61K 31/43 (2006.01); A61K 31/4402 (2006.01); A61K 31/4439 (2006.01); A61K 31/47 (2006.01); A61K 31/4748 (2006.01); A61K 31/7048 (2006.01)
CPC A61J 7/0061 (2013.01) [A61K 31/137 (2013.01); A61K 31/138 (2013.01); A61K 31/167 (2013.01); A61K 31/197 (2013.01); A61K 31/43 (2013.01); A61K 31/4402 (2013.01); A61K 31/4439 (2013.01); A61K 31/47 (2013.01); A61K 31/4748 (2013.01); A61K 31/7048 (2013.01)] 19 Claims
OG exemplary drawing
 
1. An oral drug delivery device comprising a tubular member, a drug holding part, a device cap and a turbulence-creating means, wherein the tubular member has openings at both ends and an inner cavity with a first opening at one end and a second opening at the other end, and the inner cavity communicates the first opening and the second opening; the drug holding part has a porous structure, which is retained in the inner cavity near the first opening for holding granules or multi-particulates containing active pharmaceutical ingredients; the porous structure has one or more orifices allowing the passage of liquid, and the orifices has a smaller diameter than the granules or multi-particulates containing the active pharmaceutical ingredients; the device cap is a detachable connection and is disposed outside the second opening; the turbulence-creating means comprises a step structure or a fold structure provided in the inner cavity and positioned between the second opening and the drug holding part;
wherein a cross-sectional diameter of the inner cavity at the fold structure is smaller than that of the inner cavity at a junction of the tubular member and the fold structure, and a minimum cross-sectional diameter of the inner cavity at the fold structure is not less than one-fifth of a cross-sectional diameter of the inner cavity of the tubular member;
wherein the tubular member has at least two tubular segments which are connected to each other hermetically and can be elongated or shorten axially along the tubular member, the tubular segments are connected by the telescopic nesting; when the tubular member is elongated, a turbulence-creating means with at least one step structure is formed.