US 12,186,234 B2
Topical ocular delivery methods and devices for use in the same
Yehuda Ivri, Newport Coast, CA (US); Mark S. Blumenkranz, Portola Valley, CA (US); Peter Noymer, Los Gatos, CA (US); and Daniel V. Palanker, Sunnyvale, CA (US)
Assigned to Bausch + Lomb Ireland Limited, Dublin (IE)
Filed by Bausch + Lomb Ireland Limited, Dublin (IE)
Filed on Jun. 18, 2019, as Appl. No. 16/444,894.
Application 16/444,894 is a continuation in part of application No. PCT/US2019/027018, filed on Apr. 11, 2019.
Claims priority of provisional application 62/814,764, filed on Mar. 6, 2019.
Claims priority of provisional application 62/656,552, filed on Apr. 12, 2018.
Prior Publication US 2019/0314195 A1, Oct. 17, 2019
Int. Cl. A61F 9/00 (2006.01); A61K 9/00 (2006.01); A61K 31/135 (2006.01); A61K 31/216 (2006.01); A61K 31/4178 (2006.01); A61K 31/4409 (2006.01); A61K 31/46 (2006.01); A61K 31/472 (2006.01); A61K 31/573 (2006.01); A61K 45/06 (2006.01); A61K 47/34 (2017.01); A61P 27/06 (2006.01); A61P 27/10 (2006.01)
CPC A61F 9/0008 (2013.01) [A61K 9/0048 (2013.01); A61K 31/135 (2013.01); A61K 31/216 (2013.01); A61K 31/4178 (2013.01); A61K 31/4409 (2013.01); A61K 31/46 (2013.01); A61K 31/472 (2013.01); A61K 45/06 (2013.01); A61P 27/06 (2018.01); A61P 27/10 (2018.01); A61K 31/573 (2013.01); A61K 47/34 (2013.01)] 16 Claims
OG exemplary drawing
 
1. A method of treating a subject for an ophthalmic condition, the method comprising:
providing a handheld device having a volume of liquid, an aperture through which the liquid can be ejected as a stream towards a target eye of the subject, and a concave mirror disposed downstream of the aperture and having an opening through which fluid from the aperture can be directed;
moving the handheld device until the subject can observe an image of the target eye in the concave mirror becoming focused, indicating alignment of the handheld device with the target eye; and
activating an actuator engaging the handheld device to generate pressure fluctuations within the liquid inside the handheld device and to disengage a rod disposed within the handheld device from the aperture to unseal the aperture and administer the liquid, through the aperture, to the aligned target eye.