US 12,186,221 B2
Blue light photobiomodulation
Norbert Gretz, Mannheim (DE); Fabiola Arpino, Mannheim (DE); Anja Becker, Mannheim (DE); Anna Klapczynski, Mannheim (DE); Natalia Kuch, Mannheim (DE); Marielle Bouschbacher, Chambolle-Musigny (FR); and Julien Steinbrunn, Messigny et Vantoux (FR)
Assigned to Urgo Recherche Innovation et Developpement, Chenove (FR); and Blue Light Photobiomodulation GDBR, Mannheim (DE)
Filed by Urgo Recherche Innovation et Developpement, Chenove (FR); and Blue Light Photobiomodulation GDBR, Mannheim (DE)
Filed on Nov. 12, 2020, as Appl. No. 17/095,900.
Application 17/095,900 is a division of application No. 16/321,355, abandoned, previously published as PCT/EP2017/068951, filed on Jul. 27, 2017.
Prior Publication US 2021/0059848 A1, Mar. 4, 2021
Int. Cl. A61F 13/0246 (2024.01); A61F 5/01 (2006.01); A61N 5/06 (2006.01); B29C 33/38 (2006.01); C12N 5/071 (2010.01); C12N 5/077 (2010.01); G05B 19/4099 (2006.01); G06T 7/30 (2017.01); A61F 2/50 (2006.01); B29L 31/00 (2006.01)
CPC A61F 5/0123 (2013.01) [A61F 5/01 (2013.01); A61F 13/0246 (2013.01); A61N 5/0616 (2013.01); B29C 33/3835 (2013.01); C12N 5/0629 (2013.01); C12N 5/0656 (2013.01); G05B 19/4099 (2013.01); G06T 7/30 (2017.01); A61F 2002/505 (2013.01); A61F 2002/5053 (2013.01); A61F 5/0125 (2013.01); A61N 2005/0645 (2013.01); A61N 2005/0663 (2013.01); B29L 2031/757 (2013.01); G05B 2219/35134 (2013.01); G05B 2219/49007 (2013.01); G06T 2207/30052 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A method for inducing or promoting growth and proliferation of at least one cell of keratinocytes or fibroblasts, the method comprising the steps of:
causing the at least one cell to be illuminated by operation of a light source device configured to induce or promote growth and proliferation of the at least one cell, wherein the light source device is configured to emit only blue light, and wherein the light source device comprises:
a light emitting element configured to only emit a blue light having a wavelength ranging from 435 to 500 nm and oriented to target the at least one cell of keratinocytes or fibroblasts,
the light source device being configured to provide the blue light at transmitted fluence ranging from 0.01 to 18.5 J/cm2,
wherein the light emitting element has a power density ranging from 0.05 to 30 mW/cm2
wherein the light source device is configured so that the light emitting element is selectively orientated to target the skin cells to be irradiated, and
wherein an output of the light emitting element is configurable between a first orientation and a second orientation having a different geometry of the output than in the first orientation, such that the irradiation is adaptable to a geometry and characteristics of a wound.
 
9. A method for inducing or promoting growth and proliferation of at least one cell of keratinocytes or fibroblasts, the method comprising the following steps:
providing a product adapted to be in contact with skin or a wound of a patient;
adapting a light source device connected to the product for providing blue light to the at least one cell;
causing the at least one cell to be illuminated by operation of a light source device configured to induce or promote growth and proliferation of the at least one cell, wherein the light source device is configured to emit only blue light, and wherein the light source device comprises:
a light emitting element configured to only emit a blue light having a wavelength ranging from 435 to 500 nm and oriented to target the at least one cell of keratinocytes or fibroblasts,
the light source device being configured to provide the blue light at a transmitted fluence ranging from 0.01 to 18.5 J/cm2,
wherein the light emitting element has a power density ranging from 0.05 to 30 mW/cm2,
wherein the light source device is configured so that the light emitting element is selectively orientated to target the skin cells to be irradiated, and
wherein an output of the light emitting element is configurable between a first orientation and a second orientation having a different geometry of the output than in the first orientation, such that the irradiation is adaptable to a geometry and characteristics of a wound.
 
14. A method comprising:
providing at least one cell of keratinocytes or fibroblasts in vivo or in vitro;
inducing or promoting growth and proliferation of the at least one cell of keratinocytes or fibroblasts;
wherein inducing or promoting growth and proliferation of the at least one cell comprises causing the at least one cell to be illuminated by operation of a light source device configured to induce or promote growth and proliferation of the at least one cell, wherein the light source device is configured to emit only blue light,
wherein the light source device comprises a light emitting element configured to only emit a blue light having a wavelength ranging from 435 to 500 nm oriented to target the at least one cell of keratinocytes or fibroblasts, the light source device being configured to provide the blue light at a transmitted fluence ranging from 0.01 to 18.5 J/m2, and
wherein the light emitting element has a power density ranging from 0.05 to 30 mW/cm2.