wherein the implantable vein frame includes a first ring member, a second ring member, at least one interconnecting member disposed between and interconnecting the first ring member and second ring member in a spaced relation such that the at least one interconnection member is rigid and non-expandable in a radial direction and the at least one of the at least one interconnecting members defines a protruding region, at least a portion of the protruding region extending outside of a manifold region defined as a frustoconical volume between and delimited by the first ring member and the second ring member, and wherein the first and second ring members are rigid and non-expandable;