US 12,186,104 B2
Systems and methods for correcting intravoxel and/or voxel inhomogeneity
Phillip Zhe Sun, Atlanta, GA (US)
Assigned to Emory University, Atlanta, GA (US)
Appl. No. 17/639,276
Filed by Emory University, Atlanta, GA (US)
PCT Filed Jun. 30, 2020, PCT No. PCT/US2020/040216
§ 371(c)(1), (2) Date Feb. 28, 2022,
PCT Pub. No. WO2021/040880, PCT Pub. Date Mar. 4, 2021.
Claims priority of provisional application 62/894,563, filed on Aug. 30, 2019.
Prior Publication US 2022/0342021 A1, Oct. 27, 2022
Int. Cl. G01R 33/56 (2006.01); A61B 5/00 (2006.01); G01R 33/44 (2006.01); G01R 33/483 (2006.01); G06V 10/25 (2022.01); G06V 10/98 (2022.01)
CPC A61B 5/7203 (2013.01) [G01R 33/445 (2013.01); G01R 33/483 (2013.01); G01R 33/5605 (2013.01); G01R 33/5608 (2013.01); G06V 10/25 (2022.01); G06V 10/98 (2022.01)] 19 Claims
OG exemplary drawing
 
1. A method for correcting MR data comprising:
providing an inhomogeneity field/response map of a region of interest;
wherein the inhomogeneity field/response map is a high-resolution B0 inhomogeneity field/response map;
providing MR data of the region of interest;
wherein the MR data is CEST Z-spectrum image(s)/spectrum or MT Z-spectrum image(s)/spectrum, each voxel of the MR data corresponds to a plurality of subvoxels of the B0 inhomogeneity field/response map;
registering the inhomogeneity field/response map and the MR data;
constructing a subvoxel discrete B0 response from the registered inhomogeneity field/response map;
constructing a voxel discrete Z-spectrum;
determining an intravoxel inhomogeneity correction coefficient for each voxel of at least one subregion of the region of the interest using the inhomogeneity field/response map;
wherein the determining the intravoxel inhomogeneity correction co-efficient includes deconvolving the subvoxel discrete B0 response from the voxel discrete Z-spectrum; and
correcting each voxel of the MR data of the region of interest using the intravoxel inhomogeneity correction coefficient.