US 12,186,055 B2
Quantification and analysis of angiography and perfusion
T. Bruce Ferguson, Jr., Raleigh, NC (US); and Cheng Chen, Greenville, NC (US)
Assigned to Stryker Corporation, Portage, MI (US)
Filed by Stryker Corporation, Kalamazoo, MI (US)
Filed on Mar. 28, 2022, as Appl. No. 17/656,872.
Application 17/656,872 is a continuation of application No. 16/356,766, filed on Mar. 18, 2019, granted, now 11,284,801.
Application 16/356,766 is a continuation of application No. 13/922,996, filed on Jun. 20, 2013, granted, now 10,278,585, issued on May 7, 2019.
Claims priority of provisional application 61/662,885, filed on Jun. 21, 2012.
Prior Publication US 2023/0052746 A1, Feb. 16, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/00 (2006.01); A61B 5/026 (2006.01); A61B 5/0275 (2006.01); A61K 49/00 (2006.01); G06T 7/00 (2017.01)
CPC A61B 5/0071 (2013.01) [A61B 5/0261 (2013.01); A61B 5/0275 (2013.01); A61K 49/0034 (2013.01); A61B 2505/05 (2013.01); A61B 2576/023 (2013.01); G06T 7/0016 (2013.01); G06T 2207/10064 (2013.01); G06T 2207/30104 (2013.01)] 12 Claims
OG exemplary drawing
 
1. A method for visualizing and quantifying blood flow in tissue, the method comprising at a computing system comprising one or more processors and memory storing one or more computer programs that include computer instructions, which when executed by the one or more processors, cause the computing system to:
receive a first sequence of fluorescence images of the tissue comprising at least one full phase angiography cycle of blood flow through the tissue;
calculate fluorescence intensities of the first sequence of fluorescence images;
receive a second sequence of fluorescence images of the tissue comprising at least one full phase angiography cycle of blood flow through the tissue;
calculate fluorescence intensities of the second sequence of fluorescence images;
align at least a portion of the full phase angiography cycle of the first sequence of fluorescence images with a corresponding portion of the full phase angiography cycle of the second sequence of fluorescence images;
determine, in real time, an amount of perfusion change in the tissue based on the calculated fluorescence intensities of the aligned full phase angiography cycles of the first and second sequences of fluorescence images; and
display, in real time, the determined amount of perfusion change on a display.