generating a model of a luminal network based on images of the luminal network;

determining a location of a target in the luminal network;

guiding a catheter to the target, the catheter including a medium channel and at least one medium outlet in fluid communication with the medium channel for delivering a therapy medium to the target;

isolating an area of the luminal network around the target by inflating a first balloon coupled to the catheter and inflating a second balloon coupled to the catheter distal to the first balloon such that the isolated area is disposed between the first and second inflated balloons;

passing air through a bypass channel of the catheter, the bypass channel extending distal to the isolated area and extending through the catheter distally beyond a distal end of the medium channel, wherein a distal-most end of the catheter forms a distal opening of the bypass channel through which the air exits the bypass channel for delivery into the luminal network distal to the isolated area of the luminal network;

dispensing, via the at least one medium outlet, the therapy medium within the isolated area of the luminal network to the target;

removing a volume of the therapy medium from the isolated area of the luminal network;

measuring the volume of therapy medium removed from the isolated area of the luminal network; and

determining whether the volume of the therapy medium removed from the isolated areas of the luminal network equals or exceeds a threshold volume based on a volume of the therapy medium dispensed to the isolated area of the luminal network.