US 11,852,633 B2
Compositions and methods for analyzing cysteine
Christian Wolf, Arlington, VA (US); and Fathima Yushra Thanzeel, Washington, DC (US)
Assigned to GEORGETOWN UNIVERSITY, Washington, DC (US)
Filed by Georgetown University, Washington, DC (US)
Filed on Nov. 26, 2022, as Appl. No. 17/994,322.
Application 17/994,322 is a division of application No. 16/608,147, granted, now 11,635,436, previously published as PCT/US2018/029109, filed on Apr. 24, 2018.
Claims priority of provisional application 62/489,411, filed on Apr. 24, 2017.
Prior Publication US 2023/0160903 A1, May 25, 2023
Int. Cl. G01N 33/68 (2006.01); G01N 21/33 (2006.01); G01N 21/64 (2006.01); G01N 33/52 (2006.01); C07C 309/05 (2006.01); C07C 309/73 (2006.01); C07C 309/65 (2006.01)
CPC G01N 33/6815 (2013.01) [G01N 21/33 (2013.01); G01N 21/64 (2013.01); G01N 33/52 (2013.01); C07C 309/65 (2013.01); C07C 309/73 (2013.01)] 20 Claims
OG exemplary drawing
 
1. An analytical method comprising:
contacting a sample containing D-cysteine, L-cysteine, or a mixture thereof with a probe, wherein said contacting is carried out under conditions effective to result in double ipso-substitution of any cysteine present in the sample; and
determining, based on any double ipso-substituted cysteine that forms, the absolute configuration of D/L-cysteine in the sample, and/or the enantiomeric composition of cysteine in the sample, and/or the concentration of total cysteine in the sample.