CPC C12N 15/113 (2013.01) [A61K 9/0019 (2013.01); A61K 9/0048 (2013.01); A61P 27/02 (2018.01); C12N 15/111 (2013.01); C12N 15/86 (2013.01); A61K 48/00 (2013.01); C12N 2310/113 (2013.01); C12N 2310/141 (2013.01); C12N 2320/32 (2013.01); C12N 2330/51 (2013.01); C12N 2750/14122 (2013.01); C12N 2750/14143 (2013.01)] | 4 Claims |
1. A recombinant adeno-associated virus (rAAV) comprising:
(i) a capsid protein having a serotype of AAVrh.10 encoded by the amino acid sequence set forth in SEQ ID NO: 14; and,
(ii) a nucleic acid comprising a promoter operably linked to a transgene encoding a protein associated with an ocular disease, wherein the transgene comprises a tough decoy (TuD) miRNA having a region of complementarity to SEQ ID NO:1.
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