CPC C07K 16/32 (2013.01) [C07K 16/22 (2013.01); C07K 16/2878 (2013.01); C07K 16/4283 (2013.01); C07K 16/468 (2013.01); C07K 2317/55 (2013.01); C07K 2317/56 (2013.01); C07K 2317/622 (2013.01); C07K 2317/73 (2013.01)] | 15 Claims |
1. A multispecific antibody capable of binding to a first epitope on VEGF and a second epitope on HER2, wherein the multispecific antibody comprises an antigen-binding site comprising a light chain variable domain (VL) comprising the following complementarity determining regions (CDRs):
(a) a CDR-L1 comprising the amino acid sequence of SEQ ID NO: 24,
(b) a CDR-L2 comprising the amino acid sequence of SEQ ID NO: 25, and
(c) a CDR-L3 comprising the amino acid sequence of SEQ ID NO: 26, and
a heavy chain variable domain (VH) comprising the following CDRs:
(d) a CDR-H1 comprising the amino acid sequence of SEQ ID NO: 1,
(e) a CDR-H1 comprising the amino acid sequence of SEQ ID NO: 2, and
(f) a CDR-H1 comprising the amino acid sequence of SEQ ID NO: 3, and
wherein the antigen-binding site is capable of binding to the first epitope and the second epitope.
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