CPC C07K 16/2869 (2013.01) [G01N 33/57415 (2013.01); G01N 33/57434 (2013.01); C07K 2317/565 (2013.01); G01N 2333/726 (2013.01)] | 12 Claims |
1. An isolated nucleic acid that encodes an antibody or antigen-binding portion thereof directed against the human follicle-stimulating hormone receptor (FSHR), the antibody or antigen-binding portion thereof comprising the following:
a variable heavy (VH) chain complementarity determining region (CDR)1 having the amino acid sequence SEQ ID NO: 16, wherein Xa is Q, R or K; Xb is F, Q, S or Y, Xc is Y or W, Xd is V, L, I or T, and Xe is G, I, L, Q or T,
a variable heavy (VH) chain complementarity determining region (CDR)2 having the amino acid sequence SEQ ID NO: 11, wherein Xf is F, L or Y, Xg is R or Q, Xh T or N and Xi G or Q,
a variable heavy (VH) chain complementarity determining region (CDR)3 having the amino acid sequence SEQ ID NO: 12,
a variable light chain (VL) complementarity determining region (CDR)1 having the amino acid sequence SEQ ID NO: 13,
a variable light chain (VL) complementarity determining region (CDR)2 having the amino acid sequence SEQ ID NO: 14, or
a variable light chain (VL) complementarity determining region (CDR)3 having the amino acid sequence SEQ ID NO: 15.
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