CPC C07K 16/2809 (2013.01) [A61K 31/522 (2013.01); A61K 39/395 (2013.01); A61K 47/6803 (2017.08); A61K 47/6849 (2017.08); A61K 2039/505 (2013.01); C07K 2317/55 (2013.01); C07K 2317/622 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01)] | 23 Claims |
1. An anti-human CD3 antibody, comprising (a) a heavy chain amino acid sequence comprising a sequence selected from the group consisting of SEQ ID NOs: 1, 2 and 3, (b) a light chain amino acid sequence comprising a sequence selected from the group consisting of SEQ ID NOs: 4, 5 and 6, and (c) a non-naturally encoded amino acid substituted for position 114Ala of the heavy chain, position 115Ser of the heavy chain, or position 129Lys of the heavy chain, wherein said non-naturally encoded amino acid is para-acetyl-phenylalanine, para-azido-phenylalanine or p-propargyloxyphenylalanine.
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