	US 11,851,481 B2
	Treatment of central nervous system disorders by intranasal administration of immunoglobulin g
William H. Frey, II, White Bear Lake, MN (US); Leah Ranae Bresin Hanson, Vadnais Heights, MN (US); Sharon Pokropinski, Schaumburg, IL (US); and Francisco M. Rausa, III, Vernon Hills, IL (US)
Assigned to Takeda Pharmaceutical Company Limited, Osaka (JP)
Filed by Takeda Pharmaceutical Company Limited, Osaka (JP)
Filed on Dec. 14, 2020, as Appl. No. 17/121,553.
Application 17/121,553 is a continuation of application No. 16/165,993, filed on Oct. 19, 2018, abandoned.
Application 16/165,993 is a continuation of application No. 15/335,027, filed on Oct. 26, 2016, granted, now 10,144,776.
Application 15/335,027 is a continuation of application No. 14/189,981, filed on Feb. 25, 2014, granted, now 9,556,260, issued on Jan. 31, 2017.
Claims priority of provisional application 61/862,814, filed on Aug. 6, 2013.
Claims priority of provisional application 61/769,673, filed on Feb. 26, 2013.
Prior Publication US 2021/0101967 A1, Apr. 8, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 16/18 (2006.01); A61K 9/00 (2006.01); C07K 16/06 (2006.01); A61K 9/08 (2006.01); A61K 31/4172 (2006.01); A61K 31/401 (2006.01); A61K 31/198 (2006.01); A61K 39/00 (2006.01)

CPC C07K 16/18 (2013.01) [A61K 9/0043 (2013.01); A61K 31/401 (2013.01); A61K 31/4172 (2013.01); C07K 16/06 (2013.01); A61K 9/08 (2013.01); A61K 31/198 (2013.01); A61K 2039/505 (2013.01); A61K 2039/543 (2013.01); C07K 2317/21 (2013.01); C07K 2317/55 (2013.01); C07K 2317/92 (2013.01)]

15 Claims

1. A method for delivering pooled human immunoglobulin G (IgG) to the brain of the subject, the method comprising intranasally administering a composition comprising pooled human IgG to the subject, wherein at least 40% of the pooled human IgG administered to the subject contacts the contacts the upper third of the nasal cavity of the subject.