	US 11,851,447 B2
	Dinuclear platinum(II) compounds and methods of use thereof
Christopher Pigge, Iowa City, IA (US); and Moustafa Tarek Ahmed Ibrahim Gabr, Iowa City, IA (US)
Assigned to UNIVERSITY OF IOWA RESEARCH FOUNDATION, lowa City, IA (US)
Filed by UNIVERSITY OF IOWA RESEARCH FOUNDATION, Iowa City, IA (US)
Filed on Mar. 10, 2020, as Appl. No. 16/814,423.
Claims priority of provisional application 62/816,421, filed on Mar. 11, 2019.
Prior Publication US 2020/0308208 A1, Oct. 1, 2020
Int. Cl. G01N 21/76 (2006.01); C07F 15/00 (2006.01); C07H 21/04 (2006.01); G01N 21/359 (2014.01); C12N 15/11 (2006.01); C12Q 1/34 (2006.01); C12Q 1/68 (2018.01)

CPC C07F 15/0086 (2013.01) [C07H 21/04 (2013.01); C12N 15/11 (2013.01); C12Q 1/34 (2013.01); G01N 21/359 (2013.01); G01N 21/76 (2013.01); C12Q 1/68 (2013.01); G01N 2333/916 (2013.01)]

19 Claims

1. A compound of formula (Ia) or (Ib):

	(SEQ ID NO: 1)
	GGGGTTTTGGGGGGGTTTTGGG,

	(SEQ ID NO: 2)
	AGGGTTAGGGTTAGGGTTAGGG,
	or

	(SEQ ID NO: 3)
	TGAGGGTGGGTAGGGTGGGTAA.

wherein:

A, B, C, D, E, F, J and K are aryl or heteroaryl;

L, M, Q and V are selected from the group consisting of S, O, and N; provided 2 and only 2 of the 4 are nitrogen;

X, Y, W and Z are selected from the group consisting of S, O, and N; provided 2 and only 2 of the 4 are nitrogen;

wherein CWXAEQLJ is a mirror image of DZYBFVMK and CWXAE is a mirror image of DZYBF;

or a salt thereof.