CPC C07D 493/10 (2013.01) [A61K 31/35 (2013.01); A61K 31/351 (2013.01); A61K 31/357 (2013.01); A61K 31/4025 (2013.01); A61K 31/695 (2013.01); A61K 45/06 (2013.01); C07D 309/14 (2013.01)] | 11 Claims |
1. A compound of the Formula I, or a pharmaceutically acceptable salt or antibody conjugate thereof:
wherein
the dashed lines in the ring comprising X1 are double or single bonds;
X1 is selected from the group consisting of CH and N if X1 is doubly bonded to an adjacent carbon atom; or
X1 is selected from the group consisting of O, CH2, and NH if X1 is singly bonded to an adjacent carbon atom;
A is
wherein:
R1a is H or alkyl;
R5 and R8-R12 are each independently selected from the group consisting of H and alkyl;
R6 and R7, together, form a double bond or a cycloalkyl group; and
R13 is —C(O)R16, wherein R16 is —NR17R18, wherein R17 and R18 together with the nitrogen atom to which they are bound, form a 5- to 6-membered heterocyclic ring.
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