US 11,851,391 B2
Antifungal compounds and methods of forming the same
Sylvie Garneau-Tsodikova, Lexington, KY (US); David S. Watt, Lexington, KY (US); and Nishad Thamban Chandrika, Lexington, KY (US)
Assigned to University of Kentucky Research Foundation, Lexington, KY (US)
Filed by University of Kentucky Research Foundation, Lexington, KY (US)
Filed on Jul. 17, 2019, as Appl. No. 16/514,276.
Claims priority of provisional application 62/699,732, filed on Jul. 17, 2018.
Prior Publication US 2020/0024224 A1, Jan. 23, 2020
Int. Cl. C07C 281/18 (2006.01); C07C 243/10 (2006.01); A61P 31/10 (2006.01); C07C 277/00 (2006.01)
CPC C07C 243/10 (2013.01) [A61P 31/10 (2018.01); C07C 277/00 (2013.01)] 8 Claims
OG exemplary drawing
 
1. An antifungal composition comprising a compound according to Formula (I):

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof;
wherein each R is independently selected from the group consisting of H and a lower alkyl; and
wherein each X is independently selected from the group consisting of phenyl, a substituted phenyl, an aromatic heterocycle, and a substituted aromatic heterocycle, so long as when both R are H or methyl then at least one X is not phenyl or meta-methoxy substituted phenyl;
wherein the substituted phenyl comprises a substitution selected from the group consisting of nitro, an alkyl, an alkoxy, a halogen, cyano, a carboxylic acid, a sulfonic acid, aryl sulfoxides, aryl sulfones, a trihalomethyl, and combinations thereof; and
aromatic heterocycle or the substituted aromatic heterocycle comprises one or more heteroatoms selected from the group consisting nitrogen, oxygen, sulfur, and combinations thereof, wherein the aryl sulfoxides include S(═O)C6H4Z, with Z being selected from the group consisting of alkyl, alkoxy, and halogen.