US 11,850,329 B2
Methods of making a layered consolidated UHMWPE for use as a medical implant, and products made by the methods
Ebru Oral, Newton, MA (US); and Orhun K. Muratoglu, Cambridge, MA (US)
Assigned to The General Hospital Corporation, Boston, MA (US)
Filed by THE GENERAL HOSPITAL CORPORATION, Boston, MA (US)
Filed on Apr. 5, 2021, as Appl. No. 17/222,398.
Application 15/653,977 is a division of application No. 14/584,519, filed on Dec. 29, 2014, granted, now 9,731,047.
Application 14/584,519 is a division of application No. 13/202,014, granted, now 8,933,145, issued on Jan. 13, 2015, previously published as PCT/US2010/024935, filed on Feb. 22, 2010.
Application 17/222,398 is a continuation of application No. 16/229,400, filed on Dec. 21, 2018, granted, now 10,967,100.
Application 16/229,400 is a continuation of application No. 15/653,977, filed on Jul. 19, 2017, abandoned.
Claims priority of provisional application 61/154,134, filed on Feb. 20, 2009.
Prior Publication US 2021/0228775 A1, Jul. 29, 2021
Int. Cl. C08F 2/46 (2006.01); C08F 2/50 (2006.01); C08G 61/04 (2006.01); A61L 27/50 (2006.01); C08J 3/20 (2006.01); C08J 3/24 (2006.01); C08J 3/28 (2006.01); B65B 55/08 (2006.01); B65B 55/10 (2006.01); B65B 55/16 (2006.01); B65B 55/18 (2006.01); A61L 27/16 (2006.01); A61L 29/04 (2006.01); A61L 29/14 (2006.01); A61L 31/04 (2006.01); A61L 31/14 (2006.01); C08K 5/134 (2006.01)
CPC A61L 27/50 (2013.01) [A61L 27/16 (2013.01); A61L 27/505 (2013.01); A61L 29/041 (2013.01); A61L 29/14 (2013.01); A61L 29/143 (2013.01); A61L 31/048 (2013.01); A61L 31/14 (2013.01); A61L 31/143 (2013.01); B65B 55/08 (2013.01); B65B 55/10 (2013.01); B65B 55/16 (2013.01); B65B 55/18 (2013.01); C08J 3/203 (2013.01); C08J 3/247 (2013.01); C08J 3/28 (2013.01); C08K 5/134 (2013.01); C08J 2323/06 (2013.01)] 8 Claims
 
1. A method of making a layered consolidated UHMWPE for use as a medical implant, wherein the method comprises the steps of:
blending a first ultrahigh molecular weight polyethylene (UHMWPE) powder, flakes or particles with at least one pharmaceutical agent excluding vitamin-E in a solvent that comprises water and ethanol to provide a first UHMWPE blend;
drying the first UHMWPE blend;
consolidating as layers the UHMWPE blend from drying step with a second UHMWPE without blending to a pharmaceutical agent to yield layered consolidated UHMWPE comprising at least one pharmaceutical agent excluding vitamin-E in one layer; and
machining the layered consolidated UHMWPE.