US 11,850,294 B2
Buffered microencapsulated compositions and methods
Mark A. Latta, Omaha, NE (US); Stephen M. Gross, Omaha, NE (US); and William A McHale, Collegeville, PA (US)
Assigned to Premier Dental Products Company, Plymouth Meeting, PA (US)
Filed by Premier Dental Products Company, Plymouth Meeting, PA (US)
Filed on Nov. 23, 2021, as Appl. No. 17/456,271.
Application 16/577,416 is a division of application No. 16/207,545, filed on Dec. 3, 2018, granted, now 10,434,047, issued on Oct. 8, 2019.
Application 15/791,554 is a division of application No. 13/619,128, filed on Sep. 14, 2012, granted, now 9,814,657, issued on Nov. 14, 2017.
Application 17/456,271 is a continuation of application No. 16/577,416, filed on Sep. 20, 2019, granted, now 11,185,480.
Application 16/207,545 is a continuation of application No. 15/921,350, filed on Mar. 14, 2018, granted, now 10,688,026, issued on Jun. 23, 2020.
Application 15/921,350 is a continuation in part of application No. 15/791,554, filed on Oct. 24, 2017, granted, now 10,434,044, issued on Oct. 6, 2019.
Application 13/619,128 is a continuation in part of application No. 12/768,696, filed on Apr. 27, 2010, granted, now 8,889,161, issued on Nov. 18, 2014.
Claims priority of provisional application 61/172,939, filed on Apr. 27, 2009.
Prior Publication US 2022/0079849 A1, Mar. 17, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 8/11 (2006.01); A61K 6/69 (2020.01); A61K 8/19 (2006.01); A61K 8/21 (2006.01); A61K 8/24 (2006.01); A61K 47/02 (2006.01); A61K 8/87 (2006.01); A61Q 19/00 (2006.01); A61Q 5/12 (2006.01); A61K 8/64 (2006.01); A61Q 5/06 (2006.01); A61Q 5/02 (2006.01); A61Q 3/02 (2006.01); A61K 9/00 (2006.01); A61K 9/50 (2006.01); A61Q 11/00 (2006.01); A61K 33/44 (2006.01); A61K 33/16 (2006.01); A61K 33/06 (2006.01); A61Q 13/00 (2006.01); A61Q 17/00 (2006.01); A61Q 17/02 (2006.01); A61K 6/20 (2020.01); A61K 6/71 (2020.01)
CPC A61K 8/11 (2013.01) [A61K 6/20 (2020.01); A61K 6/69 (2020.01); A61K 6/71 (2020.01); A61K 8/19 (2013.01); A61K 8/21 (2013.01); A61K 8/24 (2013.01); A61K 8/64 (2013.01); A61K 8/87 (2013.01); A61K 9/0056 (2013.01); A61K 9/5031 (2013.01); A61K 9/5089 (2013.01); A61K 33/06 (2013.01); A61K 33/16 (2013.01); A61K 33/44 (2013.01); A61K 47/02 (2013.01); A61Q 3/02 (2013.01); A61Q 5/02 (2013.01); A61Q 5/06 (2013.01); A61Q 5/12 (2013.01); A61Q 11/00 (2013.01); A61Q 13/00 (2013.01); A61Q 17/005 (2013.01); A61Q 17/02 (2013.01); A61Q 19/00 (2013.01); A61K 2300/00 (2013.01); A61K 2800/412 (2013.01); A61K 2800/56 (2013.01)] 20 Claims
 
1. A composition comprising a plurality of first microcapsules and a plurality of second microcapsules, said plurality of first microcapsules comprising a polymer substantially disposed as a semipermeable shell around a positively charged ion and said plurality of second microcapsules comprising a polymer substantially disposed as a semipermeable shell around a negatively charged ion in said plurality of second microcapsules, wherein each of the positively charged ion and the negatively charged ion permeate the semipermeable shell, and wherein the composition is suitable for delivery to a mammal.