CPC A61K 35/34 (2013.01) [A61K 38/005 (2013.01); A61P 9/00 (2018.01)] | 18 Claims |
1. A method of producing a mature cardiomyocyte from an immature cardiomyocyte comprising contacting the immature cardiomyocyte with an mTOR inhibitor after the immature cardiomyocyte begins beating and/or after the immature cardiomyocyte begins expressing at least one of troponin T, troponin I, myosin heavy chain 6, or myosin heavy chain 7, and wherein the mature cardiomyocyte exhibits increased expression of REST and/or GATA4 as compared to an immature cardiomyocyte.
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