CPC A01K 67/0276 (2013.01) [C12N 9/1205 (2013.01); C12N 9/14 (2013.01); C12N 9/22 (2013.01); C12N 15/8509 (2013.01); C12N 15/87 (2013.01); C12N 15/907 (2013.01); A01K 2217/05 (2013.01); A01K 2217/054 (2013.01); A01K 2217/056 (2013.01); A01K 2217/20 (2013.01); A01K 2217/206 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0331 (2013.01); A01K 2267/0387 (2013.01); C12N 2015/8536 (2013.01)] | 21 Claims |
1. A genetically engineered rat, or progeny of the rat, whose genome comprises a homozygous knock-out of the interleukin 2 receptor subunit gamma (Il2rg) gene and a homozygous knock-out of the recombination activating gene 1 (Rag 1) gene, wherein the rat or its progeny exhibits Severe Combined Immunodeficiency (SCID), wherein the rat or its progeny has decreased levels of mature T-cells, B-cells and NK-cells, as compared to a rat not comprising the knock-out of the Il2rg gene and the knock-out of the Rag1 gene.
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