US 11,836,430 B2
FPGA-based resequencing analysis method and device
Yinlong Xie, Shenzhen (CN); Weihua Huang, Shenzhen (CN); Chen Chen, Shenzhen (CN); and Jingbo Tang, Shenzhen (CN)
Assigned to MGI TECH CO., LTD., Shenzhen (CN)
Appl. No. 17/275,075
Filed by MGI TECH CO., LTD., Shenzhen (CN)
PCT Filed Oct. 23, 2018, PCT No. PCT/CN2018/111357
§ 371(c)(1), (2) Date Mar. 10, 2021,
PCT Pub. No. WO2020/082224, PCT Pub. Date Apr. 30, 2020.
Prior Publication US 2022/0058321 A1, Feb. 24, 2022
Int. Cl. G06F 30/331 (2020.01); G06F 30/20 (2020.01); G06F 9/30 (2018.01); G06F 9/345 (2018.01); G06F 9/48 (2006.01); G06N 3/126 (2023.01)
CPC G06F 30/331 (2020.01) [G06F 9/30123 (2013.01); G06F 9/345 (2013.01); G06F 9/4881 (2013.01); G06F 30/20 (2020.01); G06N 3/126 (2013.01)] 8 Claims
OG exemplary drawing
 
1. A Field-Programmable Gate Array (FPGA)-based resequencing analysis method, comprising:
receiving genome resequencing data;
taking the genome resequencing data as an input of an FPGA, determining an alignment result in a process of resequencing based on an output of the FPGA, and at the same time, sorting and deduplicating the alignment result;
subjecting a sorted and deduplicated alignment result to correction in accordance with a base quality value; and
detecting a variation result based on a corrected alignment result.