	US 11,835,516 B2
	Determination method and kit for determining possibility of reduced renal function
Jun Wada, Okayama (JP); Koki Mise, Okayama (JP); and Masao Yamada, Kanagawa (JP)
Assigned to National University Corporation Okayama University, Okayama (JP); and Glycotechnica Ltd., Kanagawa (JP)
Appl. No. 16/498,634
Filed by National University Corporation Okayama University, Okayama (JP); and Glycotechnica Ltd., Kanagawa (JP)
PCT Filed Mar. 27, 2018, PCT No. PCT/JP2018/012399 § 371(c)(1), (2) Date Sep. 27, 2019, PCT Pub. No. WO2018/181292, PCT Pub. Date Oct. 4, 2018.
Claims priority of application No. 2017-072324 (JP), filed on Mar. 31, 2017.
Prior Publication US 2021/0109091 A1, Apr. 15, 2021
Int. Cl. G01N 33/53 (2006.01)

CPC G01N 33/5308 (2013.01) [G01N 2400/00 (2013.01); G01N 2800/042 (2013.01); G01N 2800/044 (2013.01); G01N 2800/347 (2013.01)]

16 Claims

1. A method of determining an increased risk for reduced renal function in a subject in need thereof, comprising the steps of:

a) determining a level of at least one of Galβ1-3GalNAc and Siaα2-6Gal/GalNAc in a sample from said subject; and

b) comparing the level of said at least one of

(i) Galβ1-3GalNAc and

(ii) Siaα2-6Gal/GalNAc to a reference value,

wherein said level of at least one or both of Galβ1-3GalNAc and Siaα2-6Gal/GalNAc above said reference value indicates an increased risk of reduced renal function in said subject.