	US 11,834,513 B2
	Antibodies to MUC16 and methods of use thereof
David Spriggs, New York, NY (US); and Dharmarao Thapi, Bayside Hills, NY (US)
Assigned to Memorial Sloan Kettering Cancer Center, New York, NY (US)
Filed by Memorial Sloan Kettering Cancer Center, New York, NY (US)
Filed on Jul. 28, 2020, as Appl. No. 16/941,348.
Application 16/941,348 is a division of application No. 15/695,311, filed on Sep. 5, 2017, granted, now 10,759,869.
Application 15/695,311 is a division of application No. 14/850,675, filed on Sep. 10, 2015, granted, now 9,790,283, issued on Oct. 17, 2017.
Application 14/850,675 is a division of application No. 13/635,090, granted, now 9,169,328, issued on Oct. 27, 2015, previously published as PCT/US2011/030025, filed on Mar. 25, 2011.
Claims priority of provisional application 61/317,964, filed on Mar. 26, 2010.
Prior Publication US 2021/0309758 A1, Oct. 7, 2021
Int. Cl. A61K 39/00 (2006.01); C07K 16/30 (2006.01); G01N 33/574 (2006.01)

CPC C07K 16/3092 (2013.01) [G01N 33/57488 (2013.01); A61K 39/00117 (2018.08); A61K 2039/505 (2013.01); A61K 2039/5156 (2013.01); C07K 2317/24 (2013.01); C07K 2317/33 (2013.01); C07K 2317/34 (2013.01); C07K 2317/622 (2013.01); C07K 2317/77 (2013.01); C07K 2317/92 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/33 (2013.01); G01N 2333/705 (2013.01)]

18 Claims

1. An antibody or an antigen-binding fragment thereof, that specifically binds to a MUC16 polypeptide or to an antigenic portion thereof, wherein the amino acid sequence of the MUC16 polypeptide is:

NFSPLARRVDRVAIYEE (SEQ ID NO: 1), and

wherein the antibody comprises a variable heavy (“V_H”) chain encoded by SEQ ID NO: 08 and a variable light (“V_L”) chain encoded by SEQ ID NO: 09 or SEQ ID NO: 10.