US 11,834,482 B2
Agents modulating beta-catenin functions and methods thereof
Gerard Hilinski, Somerville, MA (US); So Youn Shim, Watertown, MA (US); Matthew Reiser Patton, Somerville, MA (US); John Hanney McGee, Somerville, MA (US); Paula Cristina Ortet, Malden, MA (US); and Gregory L Verdine, Boston, MA (US)
Assigned to FOG PHARMACEUTICALS, INC., Cambridge, MA (US)
Filed by FOG PHARMACEUTICALS, INC., Cambridge, MA (US)
Filed on Nov. 3, 2021, as Appl. No. 17/518,247.
Application 17/518,247 is a continuation of application No. 16/645,407, granted, now 11,198,713, previously published as PCT/US2018/050102, filed on Sep. 7, 2018.
Claims priority of provisional application 62/555,519, filed on Sep. 7, 2017.
Prior Publication US 2022/0213154 A1, Jul. 7, 2022
Int. Cl. A61K 38/03 (2006.01); C07K 4/00 (2006.01); C07K 14/47 (2006.01); C07K 7/08 (2006.01); A61K 38/00 (2006.01); C07K 16/28 (2006.01)
CPC C07K 14/4703 (2013.01) [A61K 38/03 (2013.01); C07K 4/00 (2013.01); C07K 7/08 (2013.01); A61K 38/00 (2013.01); C07K 16/2818 (2013.01); C07K 16/2827 (2013.01)] 21 Claims
 
1. A peptide comprising:
[X1]p1[X2]p2—X3X4X5X6X7X8X9X10—[X11]p11[X12]p12[X13]p13,
wherein:
each of p1, p2, p11, p12 and p13 is independently 0 or 1;
each of X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12, and X13 is independently an amino acid residue;
at least two of X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12, and X13 comprise side chains that are linked together to form a staple, wherein the peptide comprises a structure selected from:

OG Complex Work Unit Chemistry
wherein each X is independently an amino acid residue.