CPC C07K 14/005 (2013.01) [A61K 9/127 (2013.01); A61K 39/12 (2013.01); A61P 31/14 (2018.01); A61K 2039/5254 (2013.01); A61K 2039/5258 (2013.01); A61K 2039/54 (2013.01); A61K 2039/542 (2013.01); A61K 2039/543 (2013.01); A61K 2039/545 (2013.01); C12N 2770/36122 (2013.01); C12N 2770/36123 (2013.01); C12N 2770/36134 (2013.01); C12N 2770/36171 (2013.01)] | 34 Claims |
1. A polynucleotide encoding a recombinant alphavirus non-structural protein (nsP) polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 1 or a variant thereof comprising at least 80% identity to the amino acid sequence set forth in SEQ ID NO: 1, wherein said polypeptide or said variant thereof comprises an amino acid mutation at a position equivalent to amino acid position R532 of SEQ ID NO: 1, and/or an amino acid mutation at a position equivalent to amino acid position E1050 of SEQ ID NO: 1.
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