CPC C07D 487/14 (2013.01) | 17 Claims |
1. A compound of Formula (I):
as a pharmaceutically acceptable salt or salts thereof,
wherein
X2 is —C(R4)(R4a)— or —N(R8)—;
each R4 and R4a is independently hydrogen or C1-6 alkyl;
R7 is hydrogen or C1-6alkyl;
R7a is
one R7b is halo, C1-6alkyl, halo-C1-6alkyl, aryl-C1-6alkyl, hydroxy, C1-6alkoxy, halo-C1-6alkoxy, aryloxy, nitro, C1-6alkylthio, halo-C1-6alkylthio,
C1-6alkylsulfinyl, halo-C1-6alkylsulfinyl, C1-6alkylsulfonyl, halo-C1-6alkylsulfonyl, amino, C1-6alkylamino, di-C1-6alkylamino, —C(O)(heterocycloalkyl), or cyano; where the aryl in aryloxy and aryl-C1-6alkyl are optionally substituted with 1, 2, or 3 groups independently selected from C1-6alkyl, halo, and halo-C1-6alkyl;
the other R7b is hydrogen, halo, C1-6 alkyl, halo-C1-6 alkyl, hydroxy, C1-6alkoxy, halo-C1-6alkoxy, aryloxy, nitro, C1-6alkylthio, halo-C1-6alkylthio,
C1-6alkylsulfinyl, halo-C1-6alkylsulfinyl, C1-6alkylsulfonyl, halo-C1-6alkylsulfonyl, amino, C1-6alkylamino, di-C1-6alkylamino, —C(O)(heterocycloalkyl), or cyano; where the aryl in aryloxy and aryl-C1-6 alkyl are optionally substituted with 1, 2, or 3 groups independently selected from C1-6alkyl, halo, and halo-C1-6alkyl; and
R8 is hydrogen; C1-6alkyl; carboxy-C1-6-alkyl; halo-C1-6-alkyl; hydroxy-C1-6-alkyl; or phenyl optionally substituted with 1, 2, or 3 groups independently selected from halo, C1-6alkyl, halo-C1-6 alkyl, hydroxy, C1-6alkoxy, halo-C1-6 alkoxy, nitro, and cyano; or
a hydrate, solvate, stereoisomer, tautomer, or mixture thereof provided that the compound is not selected from Group A:
Group A
or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, tautomer, or mixture thereof.
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