CPC C07D 401/14 (2013.01) [C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01)] | 5 Claims |
1. A method for treating an ASK-1 mediated disease or condition in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound represented by Formula I or a pharmaceutically acceptable salt or ester thereof:
wherein
is selected from the groups below
R1 is selected from the group consisting of:
R2 is
X is N or C—R3;
R3 is selected from the group consisting of:
1) Hydrogen;
2) Halogen;
2) —C1-C8 alkyl;
4) -halo-C1-C8-alkyl; and
5) C1-C8 alkoxyl; and
R4 is selected from the group consisting of
wherein said ASK-1 mediated disease or condition is selected from the group consisting of nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, diabetic nephropathy, myocardial ischemia, and glomerulonephritis.
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