US 11,834,408 B2
Compounds for the treatment of SARS
Arun K. Ghosh, West Lafayette, IN (US); Monika Yadav, West Lafayette, IN (US); and Andrew Mesecar, West Lafayette, IN (US)
Assigned to Purdue Research Foundation, West Lafayette, IN (US)
Filed by Purdue Research Foundation, West Lafayette, IN (US)
Filed on May 26, 2022, as Appl. No. 17/826,061.
Claims priority of provisional application 63/194,638, filed on May 28, 2021.
Prior Publication US 2022/0396550 A1, Dec. 15, 2022
Int. Cl. C07D 207/26 (2006.01); C07D 227/087 (2006.01)
CPC C07D 207/26 (2013.01) [C07D 227/087 (2013.01)] 13 Claims
 
1. A compound of the formula (I):

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof, wherein:
R1 is -alkylene-N(H)C(O)CF3
wherein the alkylene can be substituted with alkyl;
R2 is alkyl;
R3 is 3 to 12-membered heterocyclyl; and
R4 is alkyl;
or a pharmaceutically acceptable salt thereof.
 
11. A pharmaceutical composition comprising a therapeutically effective amount of one or more compounds of claim 1 and at least one pharmaceutically acceptable excipient.