US 11,833,269 B2
Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
Xiaojie Yu, Orange, CA (US); Nicholas J. Manesis, Escondido, CA (US); and Jacob Pollock, Honolulu, HI (US)
Assigned to Allergan, Inc., Irvine, CA (US)
Filed by Allergan, Inc., Irvine, CA (US)
Filed on Oct. 8, 2019, as Appl. No. 16/595,481.
Application 14/962,897 is a division of application No. 13/667,581, filed on Nov. 2, 2012, abandoned.
Application 16/595,481 is a continuation of application No. 15/727,916, filed on Oct. 9, 2017, granted, now 10,434,214.
Application 15/727,916 is a continuation of application No. 15/609,967, filed on May 31, 2017, granted, now 9,795,711, issued on Oct. 24, 2017.
Application 15/609,967 is a continuation of application No. 14/962,897, filed on Dec. 8, 2015, granted, now 9,821,086, issued on Nov. 21, 2017.
Application 13/667,581 is a continuation in part of application No. 13/605,565, filed on Sep. 6, 2012, abandoned.
Application 13/605,565 is a continuation in part of application No. 13/603,213, filed on Sep. 4, 2012, abandoned.
Claims priority of provisional application 61/555,970, filed on Nov. 4, 2011.
Claims priority of provisional application 61/531,533, filed on Sep. 6, 2011.
Prior Publication US 2020/0030490 A1, Jan. 30, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 27/24 (2006.01); A61L 27/52 (2006.01); A61K 8/73 (2006.01); A61Q 19/08 (2006.01); A61K 8/04 (2006.01); A61L 27/26 (2006.01); A61L 27/36 (2006.01)
CPC A61L 27/24 (2013.01) [A61K 8/042 (2013.01); A61K 8/735 (2013.01); A61L 27/26 (2013.01); A61L 27/3695 (2013.01); A61L 27/52 (2013.01); A61Q 19/08 (2013.01); A61K 2800/91 (2013.01); A61L 2400/06 (2013.01); A61L 2430/34 (2013.01)] 11 Claims
 
1. A hydrogel composition comprising:
(i) about 16 mg/ml to about 24 mg/ml of a hyaluronic acid, and
(ii) about 3 mg/ml to about 6 mg/ml of a collagen,
wherein the weight ratio of the hyaluronic acid to the collagen is from 3:1 to 7:1;
wherein the hyaluronic acid is crosslinked with the collagen via a plurality of crosslink units, wherein the hyaluronic acid is crosslinked with the collagen via a water-soluble carbodiimide, wherein at least a portion of the crosslink units comprise an amide bond, and wherein the composition has a storage modulus value of between about 850 Pa and about 5,000 Pa.